Ultrasonic Homogenizer - Published Papers
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| Article No. | Title |
| UH1051 | Nigrostriatal Dysfunction in Familial Alzheimer’s Disease-Linked APPswe/PS1 E9 Transgenic Mice Sylvia |
| SYLVIA E. PEREZ, ORLY LAZAROV, JAMES B. KOPRICH, ER-YUN CHEN, VIRGINIA RODRIGUEZ-MENENDEZ, JACK W. LIPTON, SANGRAM S. SISODIA, AND ELLIOTT J. MUFSON | |
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Alzheimer’s disease (AD) is often accompanied by extrapyramidal signs attributed to nigrostriatal dysfunction. The association between amyloid deposition and nigrostriatal degeneration is essentially unknown. We showed previously that the striatum and the substantia nigra of transgenic mice harboring familial AD (FAD)-linked APPswe/PS1 E9 mutants exhibit morphological alterations accompanied by amyloid- (A ) deposition (Perez et al., 2004). In the present study,wefurther investigated the interaction betweenA deposition and dopaminergic nigrostriatal dysfunction, by correlating morphological and biochemical changes in the nigrostriatal pathway with amyloid deposition pathology in the brains of 3- to 17-month-old APPswe/PS1 E9 transgenic mice and age-matched wild-type controls. We show thatA deposition is pronounced in the striatum of APPswe/PS1 E9 mice at 6 months of age, and the extent of deposition increases in an age-dependent manner. Tyrosine hydroxylase (TH)-positive dystrophic neurites with rosette or grape-like cluster disposition are observed adjacent to A plaques and display multilaminar, multivesicular, and dense-core bodies as well as mitochondria. In addition, an age-dependent increase ofTHprotein levels are shown in nigral cells in these mutant mice. Using HPLC analysis, we found a reduction in the dopamine metabolite DOPAC in the striatum of these mice. These findings show a close association between amyloid deposition and nigrostriatal pathology and suggest that altered FAD-linked amyloid metabolism impairs, at least in part, the function of dopaminergic neurons. |
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| UH1052 | Field-induced motion of ferrofluids through immiscible viscous media: Testbed for restorative treatment of retinal detachment |
| OLIN T. MEFFORDA, ROBERT C. WOODWARDB, JONATHAN D. GOFFA, T.P. VADALAA, TIM G. ST. PIERREB, JAMES P. DAILEYC, JUDY S. RIFFLEA | |
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Biocompatible, hydrophobic ferrofluids comprised of magnetite nanoparticles dispersed in polydimethylsiloxane show promise as materials for the treatment of retinal detachment. This paper focuses on the motion of hydrophobic ferrofluid droplets traveling through viscous aqueous media, whereby the movement is induced by gradients in external fields generated by small permanent magnets. A numerical method was utilized to predict the force on a spherical droplet, and then the calculated force was used to estimate the time required for the droplet to reach the permanent magnet. The calculated forces and travel times were verified experimentally. 2006 Elsevier B.V. All rights reserved. |
